The metabolic effects of fatal cyanide poisoning.
نویسندگان
چکیده
Metabolic and toxicological data were obtained during the first 24 hours following severe and eventually fatal cyanide poisoning. Initial blood cyanide concentrations were 804 mumol/l but fell rapidly over 24 hours following cobalt edetate therapy to 15 mumol/l. However, plasma thiocyanate concentrations rose over 24 hours (147-267 mumol/l) suggesting continued tissue detoxification. The major metabolic abnormality was lactic acidosis (initial pH 7.21, blood lactate 17.5 mmol/l) which corrected over 12 hours. Despite high circulating insulin concentrations the responses of blood glucose, plasma non-esterified fatty acid, blood glycerol and 3-hydroxybutyrate suggested marked insulin resistance.
منابع مشابه
Evaluation of some Enzymatic Changes in the Liver and Kidney of Rats Following Exposure to Sublethal Concentration of Potassium Cyanide
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عنوان ژورنال:
- Postgraduate medical journal
دوره 65 770 شماره
صفحات -
تاریخ انتشار 1989